UA- Medical

UA- PCI

AMI- TT

AMI- PPCI

Abciximab

GUSTO 4 ACS- not useful

EPIC, CAPTURE- useful

ISAR REACT 2- if clopidogrel is given, useful only if troponin is elvated

ADMIRAL- useful

CADILLAC- neutral

Eptifibatide

PURSUIT- useful

PURSUIT- useful

Tirofiban

PRISM & PRISM PLUS- useful

PRISM & PRISM PLUS- useful

Enoxaparin

ESSENCE & TIMI 11 B- better than UFH

SYNERGY- as effective as UFH, but increases bleeding

ENTIRE TIMI 23

EXTRACT TIMI 25- vs heparin, decreases reinfarction

Fondaparinux

OASIS- 5 – better than enoxaparin

OASIS-5 – more catheter thrombosis when compared to enoxaparin (give UFH alongside)

OASIS-6- deceases reinfarction and death

OASIS-6- harmful compared to UFH due to catheter thrombosis

Bivalirudin

ACUITY- in patient receiving clopidogrel, bivalirudin is equivalent to UFH with GP 2b3a inhibitor and with lower bleeding

HERO-2- compared to heparin, decreases reinfarction but increases bleeding- so indicated only for HIT

HORIZONS-AMI- better than UFH