|
UA- Medical |
UA- PCI |
AMI- TT |
AMI- PPCI |
|
|
Abciximab |
GUSTO 4 ACS- not useful |
EPIC, CAPTURE- useful ISAR REACT 2- if clopidogrel is given, useful only if troponin is elvated |
ADMIRAL- useful CADILLAC- neutral |
|
|
Eptifibatide |
PURSUIT- useful |
PURSUIT- useful |
||
|
Tirofiban |
PRISM & PRISM PLUS- useful |
PRISM & PRISM PLUS- useful |
||
|
Enoxaparin |
ESSENCE & TIMI 11 B- better than UFH |
SYNERGY- as effective as UFH, but increases bleeding |
ENTIRE TIMI 23 EXTRACT TIMI 25- vs heparin, decreases reinfarction |
|
|
Fondaparinux |
OASIS- 5 – better than enoxaparin |
OASIS-5 – more catheter thrombosis when compared to enoxaparin (give UFH alongside) |
OASIS-6- deceases reinfarction and death |
OASIS-6- harmful compared to UFH due to catheter thrombosis |
|
Bivalirudin |
ACUITY- in patient receiving clopidogrel, bivalirudin is equivalent to UFH with GP 2b3a inhibitor and with lower bleeding |
HERO-2- compared to heparin, decreases reinfarction but increases bleeding- so indicated only for HIT |
HORIZONS-AMI- better than UFH |