The clinical trials in stable angina are summarized below. Hover mouse over the trial you want for defining the row.
|
Trial |
Population |
Arm 1 |
Arm 2 |
Arm 3 |
Result |
|
|
PCI vs Med |
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|
ACME |
Single or multivessel CAD |
PCI |
Med |
Same |
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|
MASS |
Proximal LAD |
PCI |
CABG |
Med |
Same |
|
|
RITA-2 |
Stable angina |
PCI |
Med |
Death or MI higher with PCI. |
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|
COURAGE |
Single or multivessel CAD |
BMS |
Med |
Same |
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|
OAT |
Post MI 3 to 28 days, asymptomatic high risk cases |
PCI |
Med |
Same |
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|
PCI vs CABG |
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|
EAST |
Multivessel |
PCI |
CABG |
Same |
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|
BARI |
Multivessel |
PCI |
CABG |
Same. DM- CABG better survival. |
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|
ARTS |
Multivessel |
BMS |
CABG |
Same. More revascularisation with PCI. DM- CABG better survival. |
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|
ARTS-2 |
Multivessel |
DES |
CABG |
Same. Equal revascularisation with PCI when compared to ARTS CABG group. |
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|
SoS |
Multivessel |
PCI |
CABG |
More mortality and revascularisation in PCI. |
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|
ERACI II |
PCI |
CABG |
Less death or MI with PCI. More revascularisation with PCI. |
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|
SYNTAX |
LMCA & TVD |
PES |
CABG |
1 year follow-up. LMCA- Major adverse cardiac or cerebrovascular events equal. More revascularisation in PCI. TVD- Both MACCE & revascularisation more in PCI. Both LMCA & TVD- Both MACCE & revascularisation more in PCI. |
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|
PRECOMBAT |
LMCA |
SES |
CABG |
Ongoing. Korea. |
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|
CABG vs Med |
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|
CASS |
CABG |
Med |
CABG better. |
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|
ECSS |
CABG |
Med |
CABG better. |
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|
VACS |
CABG |
Med |
CABG better. |
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|
Medical |
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|
Antiplatelet trialists’ collaboration |
Aspirin |
Decreases mortality |
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|
CHARISMA |
Stable angina |
Dual antiplatelet |
Aspirin |
Same |
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|
CAPRIE |
Stable angina |
Clopidogrel |
Aspirin |
Clopidogrel was better than aspirin |
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|
HOPE |
Stable angina |
Ramipril |
Placebo |
Ramipril was better than placebo. |
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|
EUROPA |
Stable angina |
Perindopril |
Perindopril was useful. |
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|
WHI |
Stable angina |
HRT in postmenopausal women |
Harmful |
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|
BEAUTIFUL |
Stable angina and systolic dysfunciton |
Ivabradine |
Placebo |
With heart rate more than 70/mt, ivabradine reduces coronary endpoints. Considering all patients, there was no benefit. |
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|
INITIATIVE |
Stable angina |
Ivabradine |
Atenolol |
Similar |
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