• Famotidine 20 mg bid vs placebo in patients taking low dose aspirin
  • Endoscopy in the beginning and after 12 weeks
  • Less gastric ulcer, duodenal ulcer and erosive esophagitis in the famotidine group.
  • Similar trial- ASTERIX trial- omeprazole 20 mg daily reduced peptic ulcers in patients taking aspirin.
  • Lancet 2009;374:119-25.